People with migraines have differences in an area of the brain that helps process sensory information, including pain, according to a study published in the November 20, 2007 issue of Neurology, the medical journal of the American Academy of Neurology.

The study, which was supported by grants from the National Institutes of Health, the Swiss Heart Foundation, and the Harvard School of Dental Medicine Dean's Award, found that part of the cortex area of the brain is thicker in people with migraine than in people who do not have the neurological disorder.

Comparing 24 people with migraine to 12 people without migraine, the study found that the somatosensory cortex area of the brain was an average of 21 percent thicker in those with migraine.

"Repeated migraine attacks may lead to, or be the result of, these structural changes in the brain," says study author Nouchine Hadjikhani, M.D., associate professor of radiology at Harvard Medical School in Boston, MA. "Most of these people had been suffering from migraines since childhood, so the long-term overstimulation of the sensory fields in the cortex could explain these changes. It's also possible that people who develop migraines are naturally more sensitive to stimulation."

Dr. Hadjikhani says the results indicate that the brain's sensory mechanisms are important components in migraine. "This may explain why people with migraines often also have other pain disorders such as back pain, jaw pain, and other sensory problems such as allodynia, where the skin becomes so sensitive that even a gentle breeze can be painful."

What this means for people with migraine, says Dr. Hadjikhani, is that pain should not be ignored or dismissed. "Pain might have negative consequences on the brain, so people should treat early. Don't play it tough," Dr. Hadjikhani says. "You could be training your brain to tolerate pain better, and this might not be a good thing."